Isotretinoin Online


Buy Accutane (Isotretinoin) anti-acne medicine online
Cheap qualitative Isotretinoin 5, 10, 20, 30, 40 mg pills



HOW AND WHERE TO BUY ISOTRETINOIN (ACCUTANE) 5 MG, 10 MG, 20 MG, 30 MG, 40 MG CAPSULES OR TABLETS ONLINE:


PHARMA SHOP

Lowest prices
Good quality
from $0.56 per pill
10% discount coupon: hf-5478



DRUGS FOR HEALTH

Low prices
High quality
from $0.68 per pill
5% discount coupon: A1XKPKC



GENERIC DRUGS SHOP

Average prices
Best quality
from $1.08 per pill
15% discount coupon: qRr3ZyvhPv


For more offers please visit
PHARMA DOCTOR: ISOTRETINOIN



ACCUTANE (ISOTRETINOIN) CAPSULES: NONCLINICAL TOXICOLOGY

Carcinogenesis, Mutagenesis and Impairment of Fertility

In male and female Fischer 344 rats given oral Accutane (Isotretinoin) at dosages of 8 or 32 mg/kg/day (1.3 to 5.3 times the recommended clinical dose of 1.0 mg/kg/day, respectively, after normalization for total body surface area) for greater than 18 months, there was a dose-related increased incidence of pheochromocytoma relative to controls. The incidence of adrenal medullary hyperplasia was also increased at the higher dosage in both sexes. The relatively high level of spontaneous pheochromocytomas occurring in the male Fischer 344 rat makes it an equivocal model for study of this tumor; therefore, the relevance of this tumor to the human population is uncertain.

The Ames test was conducted with isotretinoin in two laboratories. The results of the tests in one laboratory were negative while in the second laboratory a weakly positive response (less than 1.6 x background) was noted in S. typhimurium TA100 when the assay was conducted with metabolic activation. No dose-response effect was seen and all other strains were negative. Additionally, other tests designed to assess genotoxicity (Chinese hamster cell assay, mouse micronucleus test, S. cerevisiae D7 assay, in vitro clastogenesis assay with human-derived lymphocytes, and unscheduled DNA synthesis assay) were all negative.

In rats, no adverse effects on gonadal function, fertility, conception rate, gestation or parturition were observed at oral dosages of isotretinoin of 2, 8, or 32 mg/kg/day (0.3, 1.3, or 5.3 times the recommended clinical dose of 1.0 mg/kg/day, respectively, after normalization for total body surface area).

In dogs, testicular atrophy was noted after treatment with oral isotretinoin for approximately 30 weeks at dosages of 20 or 60 mg/kg/day (10 or 30 times the recommended clinical dose of 1.0 mg/kg/day, respectively, after normalization for total body surface area). In general, there was microscopic evidence for appreciable depression of spermatogenesis but some sperm were observed in all testes examined and in no instance were completely atrophic tubules seen. In studies of 66 men, 30 of whom were patients with nodular acne under treatment with oral Isotretinoin (Accutane), no significant changes were noted in the count or motility of spermatozoa in the ejaculate. In a study of 50 men (ages 17 to 32 years) receiving Accutane (Isotretinoin) therapy for nodular acne, no significant effects were seen on ejaculate volume, sperm count, total sperm motility, morphology or seminal plasma fructose.

Recent posts:

  • Order Accutane (Isotretinoin) Online
  • Accutane prescribing information



    Copyright © 2016-2019 Isotretinoin.medsforsale.xyz, a division of Pharma-Doctor.com pharmaceutical network.

    Home Page | Privacy Policy | Cookies Policy | Terms of Service | Contact Us