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ACCUTANE (ISOTRETINOIN) CAPSULES: DOSAGE AND ADMINISTRATION

Isotretinoin (Accutane) should be administered with a meal.

The recommended dosage range for Accutane is 0.5 to 1.0 mg/kg/day given in two divided doses with food for 15 to 20 weeks. In studies comparing 0.1, 0.5, and 1.0 mg/kg/day,8 it was found that all dosages provided initial clearing of disease, but there was a greater need for retreatment with the lower dosages. During treatment, the dose may be adjusted according to response of the disease and/or the appearance of clinical side effects - some of which may be dose related. Adult patients whose disease is very severe with scarring or is primarily manifested on the trunk may require dose adjustments up to 2.0 mg/kg/day, as tolerated. Failure to take Accutane with food will significantly decrease absorption. Before upward dose adjustments are made, the patients should be questioned about their compliance with food instructions.

The safety of once daily dosing with Accutane (Isotretinoin) capsules has not been established. Once daily dosing is not recommended.

If the total nodule count has been reduced by more than 70% prior to completing 15 to 20 weeks of treatment, the drug may be discontinued. After a period of 2 months or more off therapy, and if warranted by persistent or recurring severe nodular acne, a second course of therapy may be initiated. The optimal interval before retreatment has not been defined for patients who have not completed skeletal growth. Long-term use of Accutane, even in low doses, has not been studied, and is not recommended. It is important that Isotretinoin (Accutane) capsules be given at the recommended doses for no longer than the recommended duration. The effect of long-term use of Accutane on bone loss is unknown.

Contraceptive measures must be followed for any subsequent course of therapy.

Information for Pharmacists

Access the iPLEDGE system via the internet or telephone to obtain an authorization and the "do not dispense to patient after" date. Accutane (Isotretinoin) pills must only be dispensed in no more than a 30-day supply.

Refills require a new prescription and a new authorization from the iPLEDGE system.

An Accutane Medication Guide must be given to the patient each time this medicine is dispensed, as required by law. This Accutane Medication Guide is an important part of the risk management program for the patient.

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